Does increased water intake prevent disease progression in autosomal dominant polycystic kidney disease?

ABSTRACT:

Background

The clinical effects of increased water intake on autosomal dominant polycystic kidney disease (ADPKD) progression are unknown.

Methods

ADPKD patients with creatinine clearance ≧ 50 mL/min/1.73 m(2) were divided into high (H-, n = 18) and free (F-, n = 16) water-intake groups, mainly according to their preference. Prior to the study, 30 patients underwent annual evaluation of total kidney volume (TKV) and 24-h urine for an average of 33 months. During the 1-year study period, TKV and 24-h urine were analyzed at the beginning and end of the study and every 4 months, respectively.

Results

During the pre-study period, urine volume (UV) in the H-group was higher (P = 0.034), but TKV and kidney function and their slopes were not significantly different between t

SUBMITTER: Higashihara E 

PROVIDER: S-EPMC4145867 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature