Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation.

ABSTRACT: The circadian clock is known to regulate a wide range of physiological and cellular processes, yet remarkably little is known about its role during embryo development. Zebrafish offer a unique opportunity to explore this issue, not only because a great deal is known about key developmental events in this species, but also because the clock starts on the very first day of development. In this study, we identified numerous rhythmic genes in zebrafish larvae, including the key transcriptional regulators neurod and cdx1b, which are involved in neuronal and intestinal differentiation, respectively. Rhythmic expression of neurod and several additional transcription factors was only observed in the developing retina. Surprisingly, these rhythms in expression commenced at a stage of development af

SUBMITTER: Laranjeiro R 

PROVIDER: S-EPMC4146392 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature