Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.

ABSTRACT: Genome-wide association studies (GWAS) have identified a large number of cancer-associated single nucleotide polymorphisms (SNPs), several of which have been associated with multiple cancer sites suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesized that SNPs associated with other cancers may be additionally associated with endometrial cancer. We examined 213 SNPs previously associated with 14 other cancers for their associations with endometrial cancer in 3758 endometrial cancer cases and 5966 controls of European ancestry from two consortia: Population Architecture Using Genomics and Epidemiology and the Epidemiology of Endometrial Cancer Consortium. Study-specific logistic regression estimates adjusted for age, body mass index and the most

SUBMITTER: Setiawan VW 

PROVIDER: S-EPMC4146418 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature