Efficacy and safety of acotiamide for the treatment of functional dyspepsia: systematic review and meta-analysis.

ABSTRACT:

Background

There are no treatments with established efficacy for this disorder so far.

Aim

To systematically review the efficacy of acotiamide in the treatment of patients with FD.

Methods

We searched main electronic databases through November 2013. RCTs evaluating the efficacy of acotiamide versus placebo in FD patients were included. Pooled risk ratio (RR) with 95% confidential interval (CI) was calculated.

Results

Six publications including seven RCTs were eligible for inclusion. The summary RR of overall improvement of FD symptoms in patients receiving acotiamide versus placebo was 1.29 (95% CI, 1.19-1.40, P < 0.00001; I(2) = 15%). Acotiamide improved the symptoms of patients with postprandial distress syndrome (PDS) (RR, 1.29; 95% CI, 1.09-1.53, P = 0.003;

SUBMITTER: Xiao G 

PROVIDER: S-EPMC4146483 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature