Aedesin: structure and antimicrobial activity against multidrug resistant bacterial strains.

ABSTRACT: Multidrug resistance, which is acquired by both Gram-positive and Gram-negative bacteria, causes infections that are associated with significant morbidity and mortality in many clinical settings around the world. Because of the rapidly increasing incidence of pathogens that have become resistant to all or nearly all available antibiotics, there is a need for a new generation of antimicrobials with a broad therapeutic range for specific applications against infections. Aedesin is a cecropin-like anti-microbial peptide that was recently isolated from dengue virus-infected salivary glands of the Aedes aegypti mosquito. In the present study, we have refined the analysis of its structural characteristics and have determined its antimicrobial effects against a large panel of multidrug resistant

SUBMITTER: Godreuil S 

PROVIDER: S-EPMC4146511 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature