Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb.

ABSTRACT: Circuits in the brain possess the ability to orchestrate activities on different timescales, but the manner in which distinct circuits interact to sculpt diverse rhythms remains unresolved. The olfactory bulb is a classic example of a place in which slow theta and fast gamma rhythms coexist. Furthermore, inhibitory interneurons that are generally implicated in rhythm generation are segregated into distinct layers, neatly separating local and global motifs. We combined intracellular recordings in vivo with circuit-specific optogenetic interference to examine the contribution of inhibition to rhythmic activity in the mouse olfactory bulb. We found that the two inhibitory circuits controlled rhythms on distinct timescales: local, glomerular networks coordinated theta activity, regulating base

SUBMITTER: Fukunaga I 

PROVIDER: S-EPMC4146518 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature