A semi-automated technique determining the liver standardized uptake value reference for tumor delineation in FDG PET-CT.

ABSTRACT:

Background

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) has been an essential modality in oncology. We propose a semi-automated algorithm to objectively determine liver standardized uptake value (SUV), which is used as a threshold for tumor delineation.

Methods

A large spherical volume of interest (VOI) was placed manually to roughly enclose the right lobe (RL) of the liver. For each voxel in this VOI, a coefficient of variation of voxel values (CVv) was calculated for neighboring voxels within a radius of d/2. The voxel with the minimum CVv was then selected, where a 30-mm spherical VOI was placed at that voxel in accordance with PERCIST criteria. Two nuclear medicine physicians independently defined 30-mm VOIs manually on 124 stu

SUBMITTER: Hirata K 

PROVIDER: S-EPMC4146536 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature