The omega-3 fatty acid eicosapentaenoic acid is required for normal alcohol response behaviors in C. elegans.

ABSTRACT: Alcohol addiction is a widespread societal problem, for which there are few treatments. There are significant genetic and environmental influences on abuse liability, and understanding these factors will be important for the identification of susceptible individuals and the development of effective pharmacotherapies. In humans, the level of response to alcohol is strongly predictive of subsequent alcohol abuse. Level of response is a combination of counteracting responses to alcohol, the level of sensitivity to the drug and the degree to which tolerance develops during the drug exposure, called acute functional tolerance. We use the simple and well-characterized nervous system of Caenorhabditis elegans to model the acute behavioral effects of ethanol to identify genetic and environmental f

SUBMITTER: Raabe RC 

PROVIDER: S-EPMC4146551 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature