Association of cognitive functioning, incident stroke, and mortality in older adults.

ABSTRACT:

Background and purpose

Stroke increases the risk of dementia; however, bidirectional association of incident stroke and cognitive decline below dementia threshold is not well established. Also, both cognitive decline and stroke increase mortality risk.

Methods

A longitudinal population-based cohort of 7217 older adults without a history of stroke from a biracial community was interviewed at 3-year intervals. Cognitive function was assessed using a standardized global cognitive score. Stroke was determined by linkage with Medicare claims, and mortality was ascertained via the National Death Index. We used a Cox model to assess the risk of incident stroke, a joint model with a piecewise linear mixed model with incident stroke as a change point for cognitive decline process, an

SUBMITTER: Rajan KB 

PROVIDER: S-EPMC4146653 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature