Guanfacine modulates the emotional biasing of amygdala-prefrontal connectivity for cognitive control.

ABSTRACT: Functional interactions between amygdala and prefrontal cortex provide a cortical entry point for emotional cues to bias cognitive control. Stimulation of α2 adrenoceptors enhances the prefrontal control functions and blocks the amygdala-dependent encoding of emotional cues. However, the impact of this stimulation on amygdala-prefrontal interactions and the emotional biasing of cognitive control have not been established. We tested the effect of the α2 adrenoceptor agonist guanfacine on psychophysiological interactions of amygdala with prefrontal cortex for the emotional biasing of response execution and inhibition. Fifteen healthy adults were scanned twice with event-related functional magnetic resonance imaging while performing an emotional go/no-go task following administration of oral

SUBMITTER: Schulz KP 

PROVIDER: S-EPMC4146697 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature