"Wired," yet intoxicated: modeling binge caffeine and alcohol co-consumption in the mouse.

ABSTRACT:

Background

The combination of highly caffeinated "energy drinks" with alcohol (ethanol [EtOH]) has become popular among young adults and intoxication via such beverages has been associated with an elevated risk for harmful behaviors. However, there are discrepancies in the human literature regarding the effect of caffeine on alcohol intoxication, perhaps due to confounding factors such as personality type, expectancy, and history of exposure. Animal models of co-exposure are resistant to such issues; however, the consequences of voluntary co-consumption have been largely ignored in the animal literature. The primary goal of this work was to characterize a mouse model of binge caffeine and EtOH co-consumption employing the limited access "Drinking-in-the-Dark" (DID) paradigm.

Met

SUBMITTER: Fritz BM 

PROVIDER: S-EPMC4146700 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature