Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults.

ABSTRACT:

Objective

In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for detection of mycobacterial lipoarabinomannan (LAM) in urine. Our objective was to determine sensitivity and specificity of the TB LAM test for tuberculosis diagnosis.

Design

Prospective diagnostic accuracy study.

Setting

Hospital and outpatient settings in Uganda and South Africa.

Participants

HIV-infected adults with tuberculosis symptoms and/or signs.

Methods

Participants provided a fresh urine specimen for TB LAM testing, blood for mycobacterial culture, and 2 respirato

SUBMITTER: Nakiyingi L 

PROVIDER: S-EPMC4146703 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature