Altered innate immune development in HIV-exposed uninfected infants.

ABSTRACT:

Background

Early in life, HIV-exposed uninfected (HEU) infants are at an increased risk of morbidity and mortality from infectious disease compared with HIV-unexposed (UE) infants. To improve our understanding of the mechanisms underlying their increased risk, we contrasted innate immune development between HEU and UE infants in a developing world setting, where early life infectious disease risk is exceptionally high.

Methods

A prospective longitudinal cohort of HEU and UE newborns was established, and the most detailed characterization to date of HEU infant immune development was performed. Single-cell cytokine production was analyzed by flow cytometry after stimulation of whole blood with pathogen-associated molecular patterns (PAMPs).

Results

Monocyte, classical d

SUBMITTER: Reikie BA 

PROVIDER: S-EPMC4146715 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature