Gene expression analysis of pancreatic cystic neoplasm in SV40Tag transgenic mice model.

ABSTRACT:

Aim

To study the gene expression changes in pancreatic cystic neoplasm in SV40Tag transgenic mice model and to provide information about the prevention, clinical diagnosis and therapy of pancreatic cancer.

Methods

Using the pBC-SV40Tag transgenic mice model of pancreatic cystic neoplasm, we studied the gene expression changes by applying high-density microarrays. Validation of part gene expression profiling data was performed using real-time PCR.

Results

By using high-density oligonucleotide microarray, of 14113 genes, 453 were increased and 760 decreased in pancreatic cystic neoplasm, including oncogenes, cell-cycle-related genes, signal transduction-related genes, skeleton-related genes and metabolism-related genes. Among these, we confirmed the changes in Igf, Shh

SUBMITTER: Feng J 

PROVIDER: S-EPMC4146848 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature