Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis.

ABSTRACT: AIM:To study susceptibility genes which may play a potential role in the pathogenesis and etiology of inflammatory bowel disease (IBD). METHODS:To identify potential susceptibility genes we performed global gene expression profiling in patients with IBD and control specimens. For determination of an intrinsic gene expression profile in ulcerative colitis (UC) and Crohn's disease (CD) compared to normal subjects, mucosal biopsies of non-inflamed regions of the colon and the terminal ileum were subjected to DNA microarray analysis. Real-time RT-PCR and immunohistochemistry were used for verification of selected regulated candidate genes and a genetic analysis was performed. RESULTS:We could show that aquaporin-8 (AQP8) mRNA and protein levels were significantly increased in the colon of UC p

SUBMITTER: Zahn A 

PROVIDER: S-EPMC4146947 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature