Aberrant expression of ether a go-go potassium channel in colorectal cancer patients and cell lines.

ABSTRACT:

Aim

To study the expression of ether à go-go (Eag1) potassium channel in colorectal cancer and the relation-ship between their expression and clinico-pathological features.

Methods

The expression levels of Eag1 protein were determined in 76 cancer tissues with paired non-cancerous matched tissues as well as 9 colorectal adenoma tissues by immunohistochemistry. Eag1 mRNA expression was detected in 13 colorectal cancer tissues with paired non-cancerous matched tissues and 4 colorectal adenoma tissues as well as two colorectal cancer cell lines (LoVo and HT-29) by reverse transcription PCR.

Results

The frequency of positive expression of Eag1 protein was 76.3% (58/76) and Eag1 mRNA was 76.9% (10/13) in colorectal cancer tissue. Expression level of Eag1 protein was depend

SUBMITTER: Ding XW 

PROVIDER: S-EPMC4147004 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature