Facile non-hydrothermal synthesis of oligosaccharides coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effect.

ABSTRACT: Ultrafine sub-5 nm magnetic iron oxide nanoparticles coated with oligosaccharides (SIO) with dual T₁-T₂ weighted contrast enhancing effect and fast clearance has been developed as magnetic resonance imaging (MRI) contrast agent. Excellent water solubility, biocompatibility and high stability of such sub-5 nm SIO nanoparticles were achieved by using the "in-situ polymerization" coating method, which enables glucose forming oligosaccharides directly on the surface of hydrophobic iron oxide nanocrystals. Reported ultrafine SIO nanoparticles exhibit a longitudinal relaxivity (r₁) of 4.1 mM^-1s^-1 and a r₁/r₂ ratio of 0.25 at 3 T (clinical field strength), rendering improved T₁ or "brighter" contrast en

SUBMITTER: Huang J 

PROVIDER: S-EPMC4147377 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature