Meta-analyses of 4 CFTR variants associated with the risk of the congenital bilateral absence of the vas deferens.

ABSTRACT:

Aims

The aim of our study was to evaluate the relationship between four CFTR variations and the congenital bilateral absence of the vas deferens (CBAVD).

Methods

A systematic search was performed in the literature databases for the case-control studies of CFTR variations with the risk of CBAVD. A total of 29 studies among 1139 controls and 1562 CBAVD patients were gathered for the meta-analyses of three commonly tecsted variations (5T, ΔF508 and M470V) with CBAVD.

Results

Our meta-analyses observed significant associations between CBAVD and all the three variations, including 5T (P < 0.001, OR = 8.35, 95% CI = 6.68-10.43), M470V (P = 0.027, OR = 0.74, 95% CI = 0.60-0.91) and ΔF508 (P < 0.001, OR = 22.20, 95% CI = 7.49-65.79).

Conclusion

In the current study, we

SUBMITTER: Xu X 

PROVIDER: S-EPMC4147875 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature