Lambda: the local aligner for massive biological data.

ABSTRACT:

Motivation

Next-generation sequencing technologies produce unprecedented amounts of data, leading to completely new research fields. One of these is metagenomics, the study of large-size DNA samples containing a multitude of diverse organisms. A key problem in metagenomics is to functionally and taxonomically classify the sequenced DNA, to which end the well-known BLAST program is usually used. But BLAST has dramatic resource requirements at metagenomic scales of data, imposing a high financial or technical burden on the researcher. Multiple attempts have been made to overcome these limitations and present a viable alternative to BLAST.

Results

In this work we present Lambda, our own alternative for BLAST in the context of sequence classification. In our tests, Lambda often

SUBMITTER: Hauswedell H 

PROVIDER: S-EPMC4147892 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature