Fiona: a parallel and automatic strategy for read error correction.

ABSTRACT:

Motivation

Automatic error correction of high-throughput sequencing data can have a dramatic impact on the amount of usable base pairs and their quality. It has been shown that the performance of tasks such as de novo genome assembly and SNP calling can be dramatically improved after read error correction. While a large number of methods specialized for correcting substitution errors as found in Illumina data exist, few methods for the correction of indel errors, common to technologies like 454 or Ion Torrent, have been proposed.

Results

We present Fiona, a new stand-alone read error-correction method. Fiona provides a new statistical approach for sequencing error detection and optimal error correction and estimates its parameters automatically. Fiona is able to correct subs

SUBMITTER: Schulz MH 

PROVIDER: S-EPMC4147893 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature