Identifying transcription factor complexes and their roles.

ABSTRACT:

Motivation

Eukaryotic gene expression is controlled through molecular logic circuits that combine regulatory signals of many different factors. In particular, complexation of transcription factors (TFs) and other regulatory proteins is a prevailing and highly conserved mechanism of signal integration within critical regulatory pathways and enables us to infer controlled genes as well as the exerted regulatory mechanism. Common approaches for protein complex prediction that only use protein interaction networks, however, are designed to detect self-contained functional complexes and have difficulties to reveal dynamic combinatorial assemblies of physically interacting proteins.

Results

We developed the novel algorithm DACO that combines protein-protein interaction networks an

SUBMITTER: Will T 

PROVIDER: S-EPMC4147901 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature