ASTRAL: genome-scale coalescent-based species tree estimation.

ABSTRACT:

Motivation

Species trees provide insight into basic biology, including the mechanisms of evolution and how it modifies biomolecular function and structure, biodiversity and co-evolution between genes and species. Yet, gene trees often differ from species trees, creating challenges to species tree estimation. One of the most frequent causes for conflicting topologies between gene trees and species trees is incomplete lineage sorting (ILS), which is modelled by the multi-species coalescent. While many methods have been developed to estimate species trees from multiple genes, some which have statistical guarantees under the multi-species coalescent model, existing methods are too computationally intensive for use with genome-scale analyses or have been shown to have poor accuracy unde

SUBMITTER: Mirarab S 

PROVIDER: S-EPMC4147915 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature