Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.

ABSTRACT:

Purpose

Deregulated expression of miRNAs plays a role in the pathogenesis and progression of multiple myeloma. Among upregulated miRNAs, miR-21 has oncogenic potential and therefore represents an attractive target for the treatment of multiple myeloma.

Experimental design

Here, we investigated the in vitro and in vivo anti-multiple myeloma activity of miR-21 inhibitors.

Results

Either transient-enforced expression or lentivirus-based constitutive expression of miR-21 inhibitors triggered significant growth inhibition of primary patient multiple myeloma cells or interleukin-6-dependent/independent multiple myeloma cell lines and overcame the protective activity of human bone marrow stromal cells. Conversely, transfection of miR-21 mimics significantly increased prolife

SUBMITTER: Leone E 

PROVIDER: S-EPMC4147955 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature