PAX8/PPARγ rearrangement in thyroid nodules predicts follicular-pattern carcinomas, in particular the encapsulated follicular variant of papillary carcinoma.

ABSTRACT:

Background

PAX8/PPARγ rearrangement is a common genetic alteration in follicular thyroid carcinoma (FTC) and has been reported with variable frequency in papillary thyroid carcinoma (PTC). The diagnostic and phenotypic features of thyroid nodules positive for PAX8/PPARγ on preoperative examination are not well understood.

Methods

The prevalence of PAX8/PPARγ rearrangement was analyzed in a series of 2015 consecutive thyroid nodules that underwent molecular analysis on cytology specimens and in 446 surgically removed PTCs. For all PAX8/PPARγ positive cases, cytology and surgical pathology slides were examined and the available clinical records were reviewed.

Results

Twenty-two PAX8/PPARγ rearrangements were identified, including 16 detected preoperatively and 6 postope

SUBMITTER: Armstrong MJ 

PROVIDER: S-EPMC4148057 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature