Characterization of tumor-associated B-cell subsets in patients with colorectal cancer.

ABSTRACT:

Purpose

A precise understanding of the mechanisms by which human immune cell subsets affect tumor biology will be critical for successful treatment of cancer using immunotherapeutic approaches. Recent evidence suggests that B cells can both promote and inhibit the development and progression of tumors. The aim of this study was to characterize the composition of the B-cell infiltrates in colorectal cancers (CRC) in order to gain further insight into the role of B cells in CRC.

Experimental design

In this study we characterized B-cell subsets in primary tumors (n=38), metastases (n=6) and blood (n=46) of 51 patients with a diagnosis of CRC and blood of 10 healthy controls. B-cell subsets were analyzed by flow cytometry or immunohistochemistry.

Results

Peripheral blood

SUBMITTER: Shimabukuro-Vornhagen A 

PROVIDER: S-EPMC4148088 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature