HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer.

ABSTRACT: Ovarian cancer is the most lethal gynecologic malignancy. Recently, NACT (Neo Adjuvant Chemotherapy) has been tested as alternative approach for the management of ovarian cancer patients. A biological predictor helpful in selecting patients for NACT would be desirable. This study was aimed at identifying actionable mechanisms of resistance to NACT. Expression of a panel of microRNAs was screened in a discovery set of 85 patients. Analysis of the potential targets was conducted in the same RNAs by calculating significant correlations between microRNAs and genes. Quantitative fluorescent immunohistochemistry was employed in a validation set of 109 patients. MiR-193a-5p was significantly overexpressed in the NACT setting. Analysis of its potential targets demonstrated that this microRNA is al

SUBMITTER: Mariani M 

PROVIDER: S-EPMC4148105 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature