Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate the incidence of tertiary lymphoid structures in oral squamous cell carcinomas, and if present, analyse whether they were associated with clinical outcome.

Methods

Tumour samples from 80 patients with oral squamous cell carcinoma were immunohistochemically stained for B-cells, follicular dendritic cells, T-cells, germinal centre B-cells and high-endothelial venules. Some samples were section

SUBMITTER: Wirsing AM 

PROVIDER: S-EPMC4148494 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature