Association between antibody titers and protection against influenza virus infection within households.

ABSTRACT:

Background

Previous studies have established that antibody titer measured by the hemagglutination-inhibiting (HAI) assay is correlated with protection against influenza virus infection, with an HAI titer of 1:40 generally associated with 50% protection.

Methods

We recruited index cases with confirmed influenza virus infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. Serum samples collected from a subset of household contacts were tested by HAI and microneutralization (MN) assays against prevalent influenza viruses. We analyzed the data using an individual hazard-based transmission model that adjusted for age and vaccination history.

Results

Compared to a reference group with antibody titers <1:10

SUBMITTER: Tsang TK 

PROVIDER: S-EPMC4148604 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature