Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs.

ABSTRACT: The transient receptor potential vanilloid 1 (TRPV1) ion channel is a polymodal protein that responds to various stimuli, including capsaicin (the pungent compound found in chili peppers), extracellular acid, and basic intracellular pH, temperatures close to 42 °C, and several lipids. Lysophosphatidic acid (LPA), an endogenous lipid widely associated with neuropathic pain, is an agonist of the TRPV1 channel found in primary afferent nociceptors and is activated by other noxious stimuli. Agonists or antagonists of lipid and other chemical natures are known to possess specific structural requirements for producing functional effects on their targets. To better understand how LPA and other lipid analogs might interact and affect the function of TRPV1, we set out to determine the structural fe

SUBMITTER: Morales-Lazaro SL 

PROVIDER: S-EPMC4148841 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature