Renal growth in isolated methylmalonic acidemia.

ABSTRACT:

Purpose

We sought to predict renal growth based on clinical and metabolic parameters in patients with isolated methylmalonic acidemia, a group of disorders associated with chronic kidney disease.

Methods

Fifty patients with methylmalonic acidemia, followed from 2004 to 2011, were classified by molecular genetics and studied using a combined cross-sectional and longitudinal design that included renal ultrasound examinations, anthropometric measurements, and metabolic phenotyping. Renal length was compared with that of healthy controls and modeled to other clinical parameters using multiple-regression analyses.

Results

Comparisons with age-matched controls showed that renal length in subjects with methylmalonic acidemia was significantly decreased (P < 0.05). Stepwise r

SUBMITTER: Kruszka PS 

PROVIDER: S-EPMC4149057 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature