Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.

ABSTRACT:

Background

APOE is the biomarker with the greatest known influence on cognitive function; however, the effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations.

Methods

We evaluated APOE polymorphisms using multiplex PCR for genotyping and Mini-Mental State Examination (MMSE) to evaluate cognitive function in 819 individuals from VA Normative Aging Study.

Results

Combinatorial analysis of all polymorphisms and individual analysis of polymorphisms rs449647, rs405509, rs440446 and rs7412 did not show any association with cognitive performance. Polymorphism rs429358 was associated with better cognitive performance (odds of MMSE ≤ 25 = 0.63, 95% CI 0.42-0.95; p = 0.03) in the oldest

SUBMITTER: Prada D 

PROVIDER: S-EPMC4149270 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature