Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.

ABSTRACT:

Objective

To examine the relationship between asymmetric dimethylarginine (ADMA) and HIV-associated pulmonary arterial hypertension (PAH).

Design

HIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. Chronic inflammation resulting in nitric oxide-mediated endothelial dysfunction is a key mechanism underlying other types of PAH. ADMA is an endogenous inhibitor of endothelial nitric oxide synthase. Among uninfected individuals, ADMA is associated with PAH and predicts disease-related mortality.

Methods

We measured ADMA, high sensitivity C-reactive protein, interleukin-6 (IL-6), D-dimer, and pulmonary artery systolic pressure (PASP) using echocardiography in HIV-infected individuals. Right heart catheterization (RHC) was pe

SUBMITTER: Parikh RV 

PROVIDER: S-EPMC4149286 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature