Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection.

ABSTRACT: The B cell response to influenza infection of the respiratory tract contributes to viral clearance and establishes profound resistance to reinfection by related viruses. Numerous studies have measured virus-specific antibody-secreting cell (ASC) frequencies in different anatomical compartments after influenza infection and provided a general picture of the kinetics of ASC formation and dispersion. However, the dynamics of ASC populations are difficult to determine experimentally and have received little attention. Here, we applied mathematical modeling to investigate the dynamics of ASC growth, death, and migration over the 2-week period following primary influenza infection in mice. Experimental data for model fitting came from high frequency measurements of virus-specific IgM, IgG, and I

SUBMITTER: Miao H 

PROVIDER: S-EPMC4149352 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature