Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson's disease.

ABSTRACT:

Background

Parkinson's Disease (PD) is one of the most prevailing neurodegenerative diseases. Improving diagnoses and treatments of this disease is essential, as currently there exists no cure for this disease. Microarray and proteomics data have revealed abnormal expression of several genes and proteins responsible for PD. Nevertheless, few studies have been reported involving PD-specific protein-protein interactions.

Results

Microarray based gene expression data and protein-protein interaction (PPI) databases were combined to construct the PPI networks of differentially expressed (DE) genes in post mortem brain tissue samples of patients with Parkinson's disease. Samples were collected from the substantia nigra and the frontal cerebral cortex. From the microarray data, two

SUBMITTER: Rakshit H 

PROVIDER: S-EPMC4149362 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature