Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach.

ABSTRACT: Human coronavirus (HCoV), a member of Coronaviridae family, is the causative agent of upper respiratory tract infections and "atypical pneumonia". Despite severe epidemic outbreaks on several occasions and lack of antiviral drug, not much progress has been made with regard to an epitope-based vaccine designed for HCoV. In this study, a computational approach was adopted to identify a multiepitope vaccine candidate against this virus that could be suitable to trigger a significant immune response. Sequences of the spike proteins were collected from a protein database and analyzed with an in silico tool, to identify the most immunogenic protein. Both T cell immunity and B cell immunity were checked for the peptides to ensure that they had the capacity to induce both humoral and cell-mediated

SUBMITTER: Oany AR 

PROVIDER: S-EPMC4149408 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature