Systematic reverse engineering of network topologies: a case study of resettable bistable cellular responses.

ABSTRACT: A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems properties. For this purpose, we have previously developed a reverse engineering procedure to identify network topologies with high likelihood in generating desired systems properties. Our method searches the continuous parameter space of an assembly of network topologies, without enumerating individual network topologies separately as traditionally done in other reverse engineering procedures. Here we tested this CPSS (continuous parameter space search) method on a previously studied problem: the resettable bistability of an Rb-E2F gene network in regulating the quiescence-to-proliferation transition of mammalian cells. From a simplifie

SUBMITTER: Mondal D 

PROVIDER: S-EPMC4149494 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature