Modification of epigenetic patterns in low birth weight children: importance of hypomethylation of the ACE gene promoter.

ABSTRACT: There is a growing body of evidence that epigenetic alterations are involved in the pathological mechanisms of many chronic disorders linked to fetal programming. Angiotensin-converting enzyme (ACE) appears as one candidate gene that brings new insights into the epigenetic control and later development of diseases. In this view, we have postulated that epigenetic modifications in the ACE gene might show different interactions between birth weight (BW), blood pressure levels, plasma ACE activity and ACE I/D polymorphism. To explore this hypothesis, we performed a cross-sectional study to evaluate the DNA methylation of 3 CpG sites using pyrosequencing within the ACE gene promoter of peripheral blood leukocytes from 45 LBW children compared with 70 NBW children. Our results have revealed tha

SUBMITTER: Rangel M 

PROVIDER: S-EPMC4149513 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature