Identification of important nodes in directed biological networks: a network motif approach.

ABSTRACT: Identification of important nodes in complex networks has attracted an increasing attention over the last decade. Various measures have been proposed to characterize the importance of nodes in complex networks, such as the degree, betweenness and PageRank. Different measures consider different aspects of complex networks. Although there are numerous results reported on undirected complex networks, few results have been reported on directed biological networks. Based on network motifs and principal component analysis (PCA), this paper aims at introducing a new measure to characterize node importance in directed biological networks. Investigations on five real-world biological networks indicate that the proposed method can robustly identify actually important nodes in different networks, suc

SUBMITTER: Wang P 

PROVIDER: S-EPMC4149525 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature