Large vessel adventitial vasculitis characterizes patients with critical lower limb ischemia with as compared to without human immunodeficiency virus infection.

ABSTRACT:

Objectives

Whether a human immunodeficiency virus (HIV)-associated vasculitis in-part accounts for occlusive large artery disease remains uncertain. We aimed to identify the histopathological features that characterize large vessel changes in HIV sero-positive as compared to sero-negative patients with critical lower limb ischemia (CLI).

Materials and methods

Femoral arteries obtained from 10 HIV positive and 10 HIV negative black African male patients admitted to a single vascular unit with CLI requiring above knee amputation were subjected to histopathological assessment. None of the HIV positive patients were receiving antiretroviral therapy.

Results

As compared to HIV negative patients with CLI, HIV positive patients were younger (p<0.01) and had a lower prevalenc

SUBMITTER: Brand M 

PROVIDER: S-EPMC4149536 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature