Unknown

Dataset Information

0

3,6-Substituted-1,2,4,5-tetrazines: tuning reaction rates for staged labeling applications.


ABSTRACT: Cycloaddition reactions involving tetrazines have proven to be powerful bioorthogonal tools for various applications. Conceivably, sequential and selective labeling using tetrazine-based reactions can be achieved by tuning the reaction rate. By varying the substituents on tetrazines, cycloaddition rate variations of over 200 fold have been achieved with the same dienophile. Upon coupling with different dienophiles, such as norbornene, the reaction rate difference can be over 14,000 fold. These substituted tetrazines can be very useful for selective labeling under different conditions.

SUBMITTER: Wang D 

PROVIDER: S-EPMC4149905 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

3,6-Substituted-1,2,4,5-tetrazines: tuning reaction rates for staged labeling applications.

Wang Danzhu D   Chen Weixuan W   Zheng Yueqin Y   Dai Chaofeng C   Wang Ke K   Ke Bowen B   Wang Binghe B  

Organic & biomolecular chemistry 20140601 23


Cycloaddition reactions involving tetrazines have proven to be powerful bioorthogonal tools for various applications. Conceivably, sequential and selective labeling using tetrazine-based reactions can be achieved by tuning the reaction rate. By varying the substituents on tetrazines, cycloaddition rate variations of over 200 fold have been achieved with the same dienophile. Upon coupling with different dienophiles, such as norbornene, the reaction rate difference can be over 14,000 fold. These s  ...[more]

Similar Datasets

| S-EPMC2960921 | biostudies-literature
| S-EPMC10946812 | biostudies-literature
| S-EPMC10076274 | biostudies-literature
| S-EPMC2968976 | biostudies-literature
| S-EPMC2983408 | biostudies-literature
| S-EPMC2961757 | biostudies-literature
| S-EPMC3254257 | biostudies-literature
| S-EPMC3793835 | biostudies-literature
| S-EPMC7157563 | biostudies-literature
| S-EPMC7725851 | biostudies-literature