Signaling through FcRγ-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses.

ABSTRACT:

Background

Although allergic sensitization can be generated against various allergens, it is unknown how such a diversity of antigens is able to promote TH2-mediated inflammation leading to atopy. Our previous studies demonstrated that allergen-specific IgG immune complexes (ICs) and house dust mite (HDM) extract both induced dendritic cells (DCs) to drive TH2-mediated inflammation, but the mechanism by which these diverse stimuli produce similar responses is unknown.

Objective

We sought to identify the DC signaling pathways used by TH2 stimuli to promote TH2-mediated inflammation.

Methods

C57BL/6, FcγRIII(-/-), FcRγ(-/-), and ST2(-/-) mice were sensitized and challenged with HDM, and inflammation was assessed based on results of flow cytometry and histology and cytok

SUBMITTER: Tjota MY 

PROVIDER: S-EPMC4149927 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature