Antimullerian hormone and antral follicle count are lower in female cancer survivors and healthy women taking hormonal contraception.

ABSTRACT:

Objective

To determine the impact of hormonal contraception (HC) on markers of ovarian reserve, including antimüllerian hormone (AMH) and antral follicle count (AFC).

Design

Longitudinal prospective cohort.

Setting

University hospital.

Patient(s)

Young adult female cancer survivors and healthy similar-age women.

Intervention(s)

None.

Main outcome measure(s)

Participants were followed annually to determine hormone levels and for transvaginal ultrasound. Subjects who used HC within the preceding 3 months were considered to be exposed. Linear mixed effects models were used to incorporate repeated measures and adjust for potential confounders.

Result(s)

A total of 249 women (126 survivors, 123 control subjects; average age 25.5 years) were foll

SUBMITTER: Johnson LN 

PROVIDER: S-EPMC4149933 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature