CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.

ABSTRACT:

Background

CCR10 and CCL27 make up the most skin-specific chemokine receptor/ligand pair implicated in skin allergy and inflammatory diseases, including atopic dermatitis and psoriasis. This pair is thought to regulate the migration, maintenance, or both of skin T cells and is suggested to be therapeutic targets for treatment of skin diseases. However, the functional importance of CCR10/CCL27 in vivo remains elusive.

Objective

We sought to determine the expression and function of CCR10 in different subsets of skin T cells under both homeostatic and inflammatory conditions to gain a mechanistic insight into the potential roles of CCR10 during skin inflammation.

Methods

Using heterozygous and homozygous CCR10 knockout/enhanced green fluorescent protein knockin mice, we

SUBMITTER: Xia M 

PROVIDER: S-EPMC4149943 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature