Characterization of distinct classes of differential gene expression in osteoblast cultures from non-syndromic craniosynostosis bone.

ABSTRACT: Craniosynostosis, the premature fusion of one or more skull sutures, occurs in approximately 1 in 2500 infants, with the majority of cases non-syndromic and of unknown etiology. Two common reasons proposed for premature suture fusion are abnormal compression forces on the skull and rare genetic abnormalities. Our goal was to evaluate whether different sub-classes of disease can be identified based on total gene expression profiles. RNA-Seq data were obtained from 31 human osteoblast cultures derived from bone biopsy samples collected between 2009 and 2011, representing 23 craniosynostosis fusions and 8 normal cranial bones or long bones. No differentiation between regions of the skull was detected, but variance component analysis of gene expression patterns nevertheless supports transcript

SUBMITTER: Rojas-Pena ML 

PROVIDER: S-EPMC4150121 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature