Cerebral perfusion alterations and cerebral amyloid in autosomal dominant Alzheimer disease.

ABSTRACT:

Objective

To evaluate alterations in cerebral blood flow (CBF) using arterial spin-labeled MRI in autosomal dominant Alzheimer disease (ADAD) mutation carriers (MCs) in relation to cerebral amyloid and compared with age-matched healthy controls.

Background

Recent work has identified alterations in CBF in elderly subjects with mild cognitive impairment and Alzheimer dementia using MRI. However, similar studies are lacking in ADAD. Subjects with ADAD are generally free of significant vascular disease and offer the opportunity to measure CBF early in the pathologic process before significant symptom onset when unique markers might be identified.

Methods

Fourteen MCs (presenilin-1 and amyloid beta precursor protein) (Clinical Dementia Rating [CDR] 0 = 9, CDR 0.5 = 4, CDR

SUBMITTER: McDade E 

PROVIDER: S-EPMC4150128 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature