Clinical-pathologic study of depressive symptoms and cognitive decline in old age.

ABSTRACT:

Objective

To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia.

Methods

In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations included assessment of depressive symptoms (10-item Center for Epidemiological Studies Depression Scale) and cognitive function (battery of 17 performance tests). A total of 582 individuals died during follow-up and underwent a uniform neuropathologic examination to quantify β-amyloid plaques and tau tangle density in multiple brain regions and identify neocortical Lewy bodies, hippocampal sclerosis, and gross and microscopic cerebral infarcts.

Results

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SUBMITTER: Wilson RS 

PROVIDER: S-EPMC4150132 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature