Ontology highlight
ABSTRACT:
SUBMITTER: Roh JI
PROVIDER: S-EPMC4150217 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Cell reports 20140814 4
Dilated cardiomyopathy (DCM) is a progressive heart disease characterized by left ventricular dilation and contractile dysfunction. Although many candidate genes have been identified with mouse models, few of them have been shown to be associated with DCM in humans. Germline depletion of Ncoa6, a nuclear hormone receptor coactivator, leads to embryonic lethality and heart defects. However, it is unclear whether Ncoa6 mutations cause heart diseases in adults. Here, we report that two independent ...[more]