Reconfigurable task-dependent functional coupling modes cluster around a core functional architecture.

ABSTRACT: Functional coupling across distributed brain regions varies across task contexts, yet there are stable features. To better understand the range and central tendencies of network configurations, coupling patterns were explored using functional MRI (fMRI) across 14 distinct continuously performed task states ranging from passive fixation to increasingly demanding classification tasks. Mean global correlation profiles across the cortex ranged from 0.69 to 0.82 between task states. Network configurations from both passive fixation and classification tasks similarly predicted task coactivation patterns estimated from meta-analysis of the literature. Thus, even across markedly different task states, central tendencies dominate the coupling configurations. Beyond these shared components, distinct

SUBMITTER: Krienen FM 

PROVIDER: S-EPMC4150301 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature