Clinical and genetic correlates of growth differentiation factor 15 in the community.

ABSTRACT:

Background

Growth differentiation factor 15 (GDF15), a stress-responsive cytokine produced in cardiovascular cells under conditions of inflammation and oxidative stress, is emerging as an important prognostic marker in individuals with and without existing cardiovascular disease (CVD). We therefore examined the clinical and genetic correlates of circulating GDF15 concentrations, which have not been investigated collectively.

Methods

Plasma GDF15 concentrations were measured in 2991 participants in the Framingham Offspring Study who were free of clinically overt CVD (mean age, 59 years; 56% women). Clinical correlates of GDF15 were examined in multivariable analyses. We then conducted a genomewide association study of the GDF15 concentration that included participants in the

SUBMITTER: Ho JE 

PROVIDER: S-EPMC4150608 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature