Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis.

ABSTRACT:

Objective

To follow-up previous studies highlighting a possible role for cytochrome P450, family 2, subfamily C, 19 (CYP2C19) in susceptibility to endometriosis by searching for additional variants in the CYP2C19 gene that may be associated with the disease.

Design

Case-control study.

Setting

Academic research.

Subject(s)

The cases comprised 2,271 women with surgically confirmed endometriosis; the controls comprised 939 women with self-report of no endometriosis and 1,770 unscreened population samples.

Intervention(s)

Sequencing of the CYP2C19 region and follow-up of 80 single nucleotide polymorphisms (SNPs) in two case-control samples.

Main outcome measure(s)

Allele frequency differences between cases and controls.

Result(s)

Sequencing of

SUBMITTER: Painter JN 

PROVIDER: S-EPMC4150687 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature